N , N -Dimethylsphingosine

• Supplier: Tocris Bioscience
• Catalog: 4027
• Prices: $139.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 119567-63-4
• Chemical Name: (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
• Formula: C20H41NO2
• Molecular Weight: 327.55
• Purity: >98 %
• Description: Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N -acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1 β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

Product References

N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine - N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine

Yatomi Y, Ruan F, Megidish T, Toyokuni T, Hakomori S, Igarashi Y. Biochemistry. 1996 Jan 16;35(2):626-33.

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase - N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase

Edsall LC, Van Brocklyn JR, Cuvillier O, Kleuser B, Spiegel S. Biochemistry. 1998 Sep 15;37(37):12892-8.

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic - Metabolomics implicates altered sphingolipids in chronic pain of neuropathic

Patti GJ, Yanes O, Shriver LP, Courade JP, Tautenhahn R, Manchester M, Siuzdak G. Nat Chem Biol. 2012 Jan 22;8(3):232-4.