Diphenyleneiodonium chloride

• Supplier: Tocris Bioscience
• Catalog: 3072
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 4673-26-1
• Chemical Name: [1,1'-Biphenyl]-2,2'-diyliodoniumchloride
• Formula: C12H8ClI
• Molecular Weight: 314.55
• Purity: >99 %
• Description: GPR3 agonist (EC 50 = 1 μ M); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca 2+ mobilization and β -arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

Product References

Purification and some properties of the 45 kDa diphenylene iodonium-binding - Purification and some properties of the 45 kDa diphenylene iodonium-binding

Yea CM, Cross AR, Jones OT. Biochem J. 1990 Jan 1;265(1):95-100.

Inhibition of macrophage and endothelial cell nitric oxide synthase by - Inhibition of macrophage and endothelial cell nitric oxide synthase by

Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF. FASEB J. 1991 Jan;5(1):98-103.

Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic - Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic

Tew DG. Biochemistry. 1993 Sep 28;32(38):10209-15.

Inhibitory actions of diphenyleneiodonium on endothelium-dependent - Inhibitory actions of diphenyleneiodonium on endothelium-dependent

Wang YX, Poon CI, Poon KS, Pang CC. Br J Pharmacol. 1993 Nov;110(3):1232-8.

Identification of a novel small-molecule agonist for human G protein-coupled - Identification of a novel small-molecule agonist for human G protein-coupled

Ye C, Zhang Z, Wang Z, Hua Q, Zhang R, Xie X. J Pharmacol Exp Ther. 2014 Jun;349(3):437-43.