17-DMAG hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2241
• Prices: $225.00
• Sizes: 1 mg
• Cas Number: 467214-21-7
• Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
• Formula: C32H48N4O8.HCl
• Molecular Weight: 653.21
• Purity: >99 %
• Description: Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Product References

Pharmacokinetics, tissue distribution, and metabolism of - Pharmacokinetics, tissue distribution, and metabolism of

Egorin MJ, Lagattuta TF, Hamburger DR, Covey JM, White KD, Musser SM, Eiseman JL. Cancer Chemother Pharmacol. 2002 Jan;49(1):7-19.

Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and - Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and

Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37. Epub 2005 Apr 20.

Inhibition of hsp90 compromises the DNA damage response to radiation. - Inhibition of hsp90 compromises the DNA damage response to radiation.

Dote H, Burgan WE, Camphausen K, Tofilon PJ. Cancer Res. 2006 Sep 15;66(18):9211-20.