DMF

• Supplier: Tocris Bioscience
• Catalog: 1953
• Prices: $49.00
• Sizes: 50 mg
• Function Type: Activator
• Cas Number: 624-49-7
• Chemical Name: 2(E)-Butenedioicacid1,4-dimethylester
• Formula: C6H8O4
• Molecular Weight: 144.13
• Purity: >99 %
• Description: Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite ( MMF , Cat. No. 4511) available.

Product References

Fumaric acid esters exert neuroprotective effects in neuroinflammation via - Fumaric acid esters exert neuroprotective effects in neuroinflammation via

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Bruck W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R. Brain. 2011 Mar;134(Pt 3):678-92.

Fumarates promote cytoprotection of central nervous system cells against - Fumarates promote cytoprotection of central nervous system cells against

Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ. J Pharmacol Exp Ther. 2012 Apr;341(1):274-84.