DMH-1

• Supplier: Tocris Bioscience
• Catalog: 4512
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1206711-16-1
• Chemical Name: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
• Formula: C24H20N4O
• Molecular Weight: 380.44
• Purity: >98 %
• Description: Selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC 50 = 108 nM). Exhibits no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFR β receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614).

Product References

Swimming into the future of drug discovery: in vivo chemical screens in - Swimming into the future of drug discovery: in vivo chemical screens in

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In vivo structure-activity relationship study of dorsomorphin analogues - In vivo structure-activity relationship study of dorsomorphin analogues

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. ACS Chem Biol. 2010 Feb 19;5(2):245-53.

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of - DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of

Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91.