| Name | DMH2 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4126 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1206711-14-9 |
| Chemical Name | 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Formula | C27H25N5O2 |
| Molecular Weight | 451.52 |
| Purity | >98 % |
| Description | Type I BMP receptor inhibitor (K i values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (K i = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro . Enhances liver regeneration in vivo . |
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