DMH4

• Supplier: Tocris Bioscience
• Catalog: 5580
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 515880-75-8
• Chemical Name: 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine
• Formula: C24H24N4O2
• Molecular Weight: 400.47
• Purity: >98 %
• Description: Selective VEGFR-2 inhibitor (IC 50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGF β R-I respectively). Displays antiangiogenic activity in vitro and in vivo .

Product References

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: - Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors:

Fraley ME, Rubino RS, Hoffman WF, Hambaugh SR, Arrington KL, Hungate RW, Bilodeau MT, Tebben AJ, Rutledge RZ, Kendall RL, McFall RC, Huckle WR, Coll KE, Thomas KA. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.

In vivo structure-activity relationship study of dorsomorphin analogues - In vivo structure-activity relationship study of dorsomorphin analogues

Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. ACS Chem Biol. 2010 Feb 19;5(2):245-53.