DMOG

• Supplier: Tocris Bioscience
• Catalog: 5157
• Prices: $69.00, $265.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 89464-63-1
• Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycinemethylester
• Formula: C6H9NO5
• Molecular Weight: 175.14
• Description: Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF- α ) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1 α ; promotes cell survival under hypoxic conditions.

Product References

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by - Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Science. 2001 Apr 20;292(5516):468-72. Epub 2001 Apr 5.

Prolyl hydroxylase inhibitors depend on extracellular glucose and - Prolyl hydroxylase inhibitors depend on extracellular glucose and

Lomb DJ, Desouza LA, Franklin JL, Freeman RS. Mol Pharmacol. 2009 May;75(5):1198-209.

Activation of Hif1alpha by the prolylhydroxylase inhibitor dimethyoxalyglycine - Activation of Hif1alpha by the prolylhydroxylase inhibitor dimethyoxalyglycine

Ayrapetov MK, Xu C, Sun Y, Zhu K, Parmar K, D'Andrea AD, Price BD. PLoS One. 2011;6(10):e26064.