DMP 543

• Supplier: Tocris Bioscience
• Catalog: 4408
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 160588-45-4
• Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
• Formula: C26H18F2N2O
• Molecular Weight: 412.44
• Purity: >99 %
• Description: K + channel blocker and acetylcholine release stimulator. Potently enhances K + -stimulated [ 3 H]-ACh release from rat hippocampal slices (EC 50 = 700 nM), and also increases release of dopamine and glutamate (EC 50 values are 0.25 and 0.22 μ M, respectively). Orally active in vivo ; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo .

Product References

2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active - 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active

Earl RA, Zaczek R, Teleha CA, Fisher BN, Maciag CM, Marynowski ME, Logue AR, Tam SW, Tinker WJ, Huang SM, Chorvat RJ. J Med Chem. 1998 Nov 5;41(23):4615-22.

Two new potent neurotransmitter release enhancers, - Two new potent neurotransmitter release enhancers,

Zaczek R, Chorvat RJ, Saye JA, Pierdomenico ME, Maciag CM, Logue AR, Fisher BN, Rominger DH, Earl RA. J Pharmacol Exp Ther. 1998 May;285(2):724-30.