DMXAA

• Supplier: Tocris Bioscience
• Catalog: 3428
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 117570-53-3
• Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-aceticacid
• Formula: C17H14O4
• Molecular Weight: 282.29
• Purity: >99 %
• Description: mSTING agonist; selective for mouse STING over human STING. Induces IFN- β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

Product References

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by - Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by

Phillips RM. Biochem Pharmacol. 1999 Jul 15;58(2):303-10.

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces - The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces

Shirey KA, Nhu QM, Yim KC, Roberts ZJ, Teijaro JR, Farber DL, Blanco JC, Vogel SN. J Leukoc Biol. 2011 Mar;89(3):351-7.

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and - Direct Activation of STING in the Tumor Microenvironment Leads to Potent and

Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, Woo SR, Lemmens E, Banda T, Leong JJ, Metchette K, Dubensky TW Jr, Gajewski TF. Cell Rep. 2015 May 19;11(7):1018-30.