Docosahexaenoic acid

• Supplier: Tocris Bioscience
• Catalog: 4056
• Prices: $115.00
• Sizes: 100 mg
• Cas Number: 6217-54-5
• Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoicacid
• Formula: C22H32O2
• Molecular Weight: 328.49
• Purity: >98 %
• Description: Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit A β 1-42 fibrillation and toxicity in vitro .

Product References

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. - Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.

de Urquiza AM, Liu S, Sjoberg M, Zetterstrom RH, Griffiths W, Sjovall J, Perlmann T. Science. 2000 Dec 15;290(5499):2140-4.

Human dendritic cell activities are modulated by the omega-3 fatty acid, - Human dendritic cell activities are modulated by the omega-3 fatty acid,

Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J, de Madariaga MA, Domingo JC. J Leukoc Biol. 2008 Oct;84(4):1172-82.

Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 - Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42

Hossain S, Hashimoto M, Katakura M, Miwa K, Shimada T, Shido O. J Neurochem. 2009 Oct;111(2):568-79.