Dofetilide

Name Dofetilide
Supplier Tocris Bioscience
Catalog 3687
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 115256-11-6
Chemical Name 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Formula C19H27N3O5S2
Molecular Weight 441.56
Purity >99 %
Description Selective potassium channel blocker. Blocks K V 11.1 (hERG) channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Displays class III antiarrhythmic properties.
Supplier Page Shop

Product References

UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent - UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent

Gwilt M, Arrowsmith JE, Blackburn KJ, Burges RA, Cross PE, Dalrymple HW, Higgins AJ. J Pharmacol Exp Ther. 1991 Jan;256(1):318-24.

Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes - Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes

Carmeliet E. J Pharmacol Exp Ther. 1992 Aug;262(2):809-17.

[3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ - [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+

Finlayson K, Pennington AJ, Kelly JS. Eur J Pharmacol. 2001 Feb 2;412(3):203-12.