| Name | DOI hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3757 |
| Prices | $129.00, $515.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 42203-78-1 |
| Chemical Name | 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanaminehydrochloride |
| Formula | C11H16INO2.HCl |
| Molecular Weight | 357.62 |
| Purity | >98 % |
| Description | Brain penetrant, mixed 5-HT 2A /5-HT 2C receptor agonist (K i values are 0.7, 2.4 and 20 nM for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT 2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)- α . |
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Monti JM, Jantos H. Eur J Pharmacol. 2006 Dec 28;553(1-3):163-70. Epub 2006 Sep 23.
Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD. J Pharmacol Exp Ther. 2008 Nov;327(2):316-23.