Dolastatin 10 trifluoroacetate

Name Dolastatin 10 trifluoroacetate
Supplier Tocris Bioscience
Catalog 5629
Prices $179.00
Sizes 1 mg
Function Type Inhibitor
Chemical Name N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamidetrifluoroacetate
Formula C42H68N6O6S.CF3CO2H
Molecular Weight 899.11
Purity >95 %
Description Tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (K i = 1.4 μ M) and induces tubulin aggregation in vitro .
Supplier Page Shop

Product References

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic - Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic

Bai RL, Pettit GR, Hamel E. J Biol Chem. 1990 Oct 5;265(28):17141-9.

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding - Interaction of dolastatin 10 with tubulin: induction of aggregation and binding

Bai R, Taylor GF, Schmidt JM, Williams MD, Kepler JA, Pettit GR, Hamel E. Mol Pharmacol. 1995 May;47(5):965-76.