Domperidone

Name Domperidone
Supplier Tocris Bioscience
Catalog 0269
Prices $79.00
Sizes 50 mg
Function Type Antagonist
Cas Number 57808-66-9
Chemical Name 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Formula C22H24ClN5O2
Molecular Weight 425.92
Purity >99 %
Description Peripheral dopamine D 2 -like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED 50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
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Product References

The antiemetic effects of domperidone, a novel potent gastrokinetic. - The antiemetic effects of domperidone, a novel potent gastrokinetic.

Niemegeers CJ, Schellekens KH, Janssen PA. Arch Int Pharmacodyn Ther. 1980 Mar;244(1):130-40.

Domperidone. A review of its use in diabetic gastropathy. - Domperidone. A review of its use in diabetic gastropathy.

Prakash A, Wagstaff AJ. Drugs. 1998 Sep;56(3):429-45.

Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. - Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets.

Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, Cox BF, Brioni JD, Moreland RB. Pharmacol Biochem Behav. 2005 May;81(1):211-9.