Donepezil hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5544
• Prices: $75.00, $305.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 120011-70-3
• Chemical Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-onehydrochloride
• Formula: C24H29NO3.HCl
• Molecular Weight: 415.95
• Purity: >99 %
• Description: Potent acetylcholinesterase inhibitor (IC 50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC 50 = 7138 nM for BuChE). Orally active.

Product References

Synthesis and structure-activity relationships of acetylcholinesterase - Synthesis and structure-activity relationships of acetylcholinesterase

Sugimoto H, Iimura Y, Yamanishi Y, Yamatsu K. J Med Chem. 1995 Nov 24;38(24):4821-9.

Structure of acetylcholinesterase complexed with E2020 (Aricept): implications - Structure of acetylcholinesterase complexed with E2020 (Aricept): implications

Kryger G, Silman I, Sussman JL. Structure. 1999 Mar 15;7(3):297-307.

Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. - Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.

Sugimoto H, Yamanishi Y, Iimura Y, Kawakami Y. Curr Med Chem. 2000 Mar;7(3):303-39.