Donitriptan hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4385
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 170911-68-9
• Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazinehydrochloride
• Formula: C23H25N5O2.HCl
• Molecular Weight: 439.94
• Purity: >98 %
• Description: Brain penetrant 5-HT 1B/1D agonist (pK i values are 9.3 and 9.4 for 5-HT 1D and 5-HT 1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.

Product References

Donitriptan selectively decreases jugular venous oxygen saturation in the - Donitriptan selectively decreases jugular venous oxygen saturation in the

Letienne R, Verscheure Y, Perez M, Le Grand B, Colpaert FC, John GW. J Pharmacol Exp Ther. 2003 May;305(2):749-54. Epub 2003 Feb 11.

Donitriptan decreases jugular venous oxygen saturation in rats in the absence of - Donitriptan decreases jugular venous oxygen saturation in rats in the absence of

Letienne R, Blanchet JC, Sole E, John GW, Le Grand B. J Pharmacol Exp Ther. 2005 Nov;315(2):849-57. Epub 2005 Jul 18.

Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external - Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external

Munoz-Islas E, Gupta S, Jimenez-Mena LR, Lozano-Cuenca J, Sanchez-Lopez A, Centurion D, Mehrotra S, MaassenVanDenBrink A, Villalon CM. Br J Pharmacol. 2006 Sep;149(1):82-91. Epub 2006 Jul 31.