Doxepin hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2964
• Prices: $75.00
• Sizes: 1 g
• Function Type: Antagonist
• Cas Number: 1229-29-4
• Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepinhydrochloride
• Formula: C19H21NO.HCl
• Molecular Weight: 315.84
• Purity: >99 %
• Description: Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).

Product References

[3H]doxepin interactions with histamine H1-receptors and other sites in guinea - [3H]doxepin interactions with histamine H1-receptors and other sites in guinea

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Review of clinical and animal studies comparing the cardiovascular effects of - Review of clinical and animal studies comparing the cardiovascular effects of

Luchins DJ. Am J Psychiatry. 1983 Aug;140(8):1006-9.

Discovery of a novel member of the histamine receptor family. - Discovery of a novel member of the histamine receptor family.

Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Mol Pharmacol. 2001 Mar;59(3):427-33.