Doxorubicin hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3206
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Cas Number: 25316-40-9
• Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedionehydrochloride
• Formula: C27H29NO11.HCl
• Molecular Weight: 579.99
• Purity: >98 %
• Description: Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.

Product References

Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. - Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides.

Grubb N, Weil A, Caldwell J. Biochem Pharmacol. 1993 Aug 3;46(3):357-64.

Identification of yeast DNA topoisomerase II mutants resistant to the antitumor - Identification of yeast DNA topoisomerase II mutants resistant to the antitumor

Patel S, Sprung AU, Keller BA, Heaton VJ, Fisher LM. Mol Pharmacol. 1997 Oct;52(4):658-66.

A critical evaluation of the mechanisms of action proposed for the antitumor - A critical evaluation of the mechanisms of action proposed for the antitumor

Gewirtz DA. Biochem Pharmacol. 1999 Apr 1;57(7):727-41.

Pharmacologic reductions of total tau levels; implications for the role of - Pharmacologic reductions of total tau levels; implications for the role of

Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Mol Neurodegener. 2006 Jul 26;1:6.