DPN

• Supplier: Tocris Bioscience
• Catalog: 1431
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1428-67-7
• Chemical Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile
• Formula: C15H13NO2
• Molecular Weight: 239.27
• Purity: >99 %
• Description: Highly potent estrogen ER β receptor agonist with a 70-fold selectivity over ER α (EC 50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro . Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus.

Product References

Estrogen receptor-beta potency-selective ligands: structure-activity relationship - Estrogen receptor-beta potency-selective ligands: structure-activity relationship

Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, Katzenellenbogen JA. J Med Chem. 2001 Nov 22;44(24):4230-51.

Activities of estrogen receptor alpha- and beta-selective ligands at diverse - Activities of estrogen receptor alpha- and beta-selective ligands at diverse

Harrington WR, Sheng S, Barnett DH, Petz LN, Katzenellenbogen JA, Katzenellenbogen BS. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):13-22.

Acute effects of oestrogen receptor subtype-specific agonists on vascular - Acute effects of oestrogen receptor subtype-specific agonists on vascular

Montgomery S, Shaw L, Pantelides N, Taggart M, Austin C. Br J Pharmacol. 2003 Aug;139(7):1249-53.

Estrogen receptor alpha and beta specific agonists regulate expression of - Estrogen receptor alpha and beta specific agonists regulate expression of

Waters EM, Mitterling K, Spencer JL, Mazid S, McEwen BS, Milner TA. Brain Res. 2009 Sep 22;1290:1-11.