DPO-1

• Supplier: Tocris Bioscience
• Catalog: 2991
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 43077-30-1
• Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide
• Formula: C22H29OP
• Molecular Weight: 340.44
• Purity: >99 %
• Description: Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Product References

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel - In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel

Stump GL, Wallace AA, Regan CP, Lynch JJ Jr. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7. Epub 2005 Sep 12.

Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating - Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating

Lagrutta A, Wang J, Fermini B, Salata JJ. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. Epub 2006 Mar 7.

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide - In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide

Regan CP, Wallace AA, Cresswell HK, Atkins CL, Lynch JJ Jr. J Pharmacol Exp Ther. 2006 Feb;316(2):727-32. Epub 2005 Oct 21.