| Name | DR 4485 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2496 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 402942-53-4 |
| Chemical Name | 6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-onehydrochloride |
| Formula | C26H28Cl2N2O.HCl |
| Molecular Weight | 491.88 |
| Purity | >98 % |
| Description | High affinity and selective 5-HT 7 antagonist (pK i = 8.14). Exhibits selectivity for 5-HT 7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT 7 receptor. Orally bioavailable. |
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Kikuchi C, Suzuki H, Hiranuma T, Koyama M. Bioorg Med Chem Lett. 2003 Jan 6;13(1):61-4.
Medina RA, Sallander J, Benhamu B, Porras E, Campillo M, Pardo L, Lopez-Rodriguez ML. J Med Chem. 2009 Apr 23;52(8):2384-92.