DSR 6434

• Supplier: Tocris Bioscience
• Catalog: 2958
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1059070-10-8
• Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
• Formula: C19H28N8O2
• Molecular Weight: 400.48
• Purity: >98 %
• Description: Potent TLR7 agonist (EC 50 = 7.2 nM). Activates several immune effector cells in vitro . Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Product References

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor - Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor

Nakamura T, Wada H, Kurebayashi H, McInally T, Bonnert R, Isobe Y. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72.

A novel systemically administered Toll-like receptor 7 agonist potentiates the - A novel systemically administered Toll-like receptor 7 agonist potentiates the

Adlard AL, Dovedi SJ, Telfer BA, Koga-Yamakawa E, Pollard C, Honeychurch J, Illidge TM, Murata M, Robinson DT, Jewsbury PJ, Wilkinson RW, Stratford IJ. Int J Cancer. 2014 Aug 15;135(4):820-9.