| Name | (S)-Duloxetine hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3156 |
| Prices | $59.00, $185.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 136434-34-9 |
| Chemical Name | (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanaminehydrochloride |
| Formula | C18H19NOS.HCl |
| Molecular Weight | 333.88 |
| Purity | >99 % |
| Description | High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K i values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC 50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K i = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable. |
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Wong DT, Robertson DW, Bymaster FP, Krushinski JH, Reid LR. Life Sci. 1988;43(24):2049-57.
Kasamo K, Blier P, De Montigny C. J Pharmacol Exp Ther. 1996 Apr;277(1):278-86.