DuP 697

• Supplier: Tocris Bioscience
• Catalog: 4798
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 88149-94-4
• Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
• Formula: C17H12BrFO2S2
• Molecular Weight: 411.3
• Purity: >99 %
• Description: Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.

Product References

Anti-inflammatory and safety profile of DuP 697, a novel orally effective - Anti-inflammatory and safety profile of DuP 697, a novel orally effective

Gans KR, Galbraith W, Roman RJ, Haber SB, Kerr JS, Schmidt WK, Smith C, Hewes WE, Ackerman NR. J Pharmacol Exp Ther. 1990 Jul;254(1):180-7.

Expression and selective inhibition of the constitutive and inducible forms of - Expression and selective inhibition of the constitutive and inducible forms of

Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, Isakson PC, Seibert K. Biochem J. 1995 Jan 15;305 ( Pt 2):479-84.

Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial - Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial

Rossoni G, Muscara MN, Cirino G, Wallace JL. Br J Pharmacol. 2002 Mar;135(6):1540-6.