| Name | DV 7028 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1430 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 133364-62-2 |
| Chemical Name | 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dionehydrochloride |
| Formula | C21H25FN4O3.HCl |
| Molecular Weight | 436.91 |
| Purity | >99 % |
| Description | Selective 5-HT 2A receptor antagonist (K i = 22 nM for at 5-HT 2 receptors). Exhibits no affinity for 5-HT 1A , 5-HT 1B or 5-HT 1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models. |
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Shibano T, Tanaka T, Morishima Y, Yasuoka M, Watanabe K, Fujii F. Arch Int Pharmacodyn Ther. 1992 Sep-Oct;319:114-28.
Pawlak D, Pawlak K, Chabielska E, Malyszko J, Takada A, Mysliwiec M, Buczko W. Thromb Res. 1998 Jun 15;90(6):259-70.