Dynamin inhibitory peptide

Name Dynamin inhibitory peptide
Supplier Tocris Bioscience
Catalog 2266
Prices $259.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 251634-21-6
Formula C47H80N18O14
Molecular Weight 1121.26
Description Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABA A receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABA A receptors. Cell-permeable version also available (Cat. No. 1775).
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Product References

The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a - The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a

Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P. J Biol Chem. 1997 May 16;272(20):13419-25.

Constitutive endocytosis of GABAA receptors by an association with the adaptin - Constitutive endocytosis of GABAA receptors by an association with the adaptin

Kittler JT, Delmas P, Jovanovic JN, Brown DA, Smart TG, Moss SJ. J Neurosci. 2000 Nov 1;20(21):7972-7.

Glycine binding primes NMDA receptor internalization. - Glycine binding primes NMDA receptor internalization.

Nong Y, Huang YQ, Ju W, Kalia LV, Ahmadian G, Wang YT, Salter MW. Nature. 2003 Mar 20;422(6929):302-7.