Name | E 64d |
---|---|
Supplier | Tocris Bioscience |
Catalog | 5208 |
Prices | $149.00 |
Sizes | 1 mg |
Function Type | Inhibitor |
Cas Number | 88321-09-9 |
Chemical Name | (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylicacidethylester |
Formula | C17H30N2O5 |
Molecular Weight | 342.43 |
Purity | >98 % |
Description | Inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. |
Supplier Page | Shop |
Wilcox D, Mason RW. Biochem J. 1992 Jul 15;285 ( Pt 2):495-502.
Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Autophagy. 2005 Jul;1(2):84-91. Epub 2005 Jul 31.
Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, Atomi Y, Ueno T, Ochiai A, Esumi H. Cancer Res. 2007 Oct 15;67(20):9677-84.
Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. Autophagy. 2008 Jul;4(5):659-68. Epub 2008 Apr 7.