E-4031 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4545
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 113559-13-0
• Chemical Name: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride
• Formula: C21H27N3O3S.2HCl
• Molecular Weight: 474.44
• Purity: >98 %
• Description: Selective blocker of K V 11.1 (hERG) channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Product References

Effects of the new class III antiarrhythmic drug E-4031 on myocardial - Effects of the new class III antiarrhythmic drug E-4031 on myocardial

Wettwer E, Scholtysik G, Schaad A, Himmel H, Ravens U. J Cardiovasc Pharmacol. 1991 Mar;17(3):480-7.

Effects of delayed rectifier current blockade by E-4031 on impulse generation in - Effects of delayed rectifier current blockade by E-4031 on impulse generation in

Verheijck EE, van Ginneken AC, Bourier J, Bouman LN. Circ Res. 1995 Apr;76(4):607-15.

The binding site for channel blockers that rescue misprocessed human long QT - The binding site for channel blockers that rescue misprocessed human long QT

Ficker E, Obejero-Paz CA, Zhao S, Brown AM. J Biol Chem. 2002 Feb 15;277(7):4989-98. Epub 2001 Dec 10.