EB 1089

• Supplier: Tocris Bioscience
• Catalog: 4876
• Prices: $185.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 134404-52-7
• Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
• Formula: C30H46O3
• Molecular Weight: 454.68
• Purity: >98 %
• Description: Vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro ; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Product References

Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated - Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated

Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jaattela M. Cell Death Differ. 2005 Oct;12(10):1297-309.

Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous - Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous

Lu L, Qiu J, Liu S, Luo W. Mol Cancer Ther. 2008 May;7(5):1268-74.

EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis - EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis

Bhatia V, Saini MK, Shen X, Bi LX, Qiu S, Weigel NL, Falzon M. Mol Cancer Ther. 2009 Jul;8(7):1787-98.