EB 47

Name EB 47
Supplier Tocris Bioscience
Catalog 3993
Prices $235.00, $965.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1190332-25-2
Chemical Name 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosinedihydrochloride
Formula C24H27N9O6.2HCl
Molecular Weight 610.45
Purity >99 %
Description Potent inhibitor of PARP-1 (IC 50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.
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Product References

The discovery and synthesis of novel adenosine substituted - The discovery and synthesis of novel adenosine substituted

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Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid - Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid

Gaymes TJ, Shall S, MacPherson LJ, Twine NA, Lea NC, Farzaneh F, Mufti GJ. Haematologica. 2009 May;94(5):638-46.

Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to - Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to

Ferraris DV. J Med Chem. 2010 Jun 24;53(12):4561-84.