1-EBIO

• Supplier: Tocris Bioscience
• Catalog: 4140
• Prices: $89.00, $349.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 10045-45-1
• Chemical Name: 1-Ethyl-2-benzimidazolinone
• Formula: C9H10N2O
• Molecular Weight: 162.19
• Purity: >99 %
• Description: Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

Product References

Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a - Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a

Devor DC, Singh AK, Frizzell RA, Bridges RJ. Am J Physiol. 1996 Nov;271(5 Pt 1):L775-84.

1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric - 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric

Adeagbo AS. Eur J Pharmacol. 1999 Aug 27;379(2-3):151-9.

Reduced hyperpolarization in endothelial cells of rabbit aortic valve following - Reduced hyperpolarization in endothelial cells of rabbit aortic valve following

Kusama N, Kajikuri J, Yamamoto T, Watanabe Y, Suzuki Y, Katsuya H, Itoh T. Br J Pharmacol. 2005 Oct;146(4):487-97.

Modulation of calcium-activated potassium channels induces cardiogenesis of - Modulation of calcium-activated potassium channels induces cardiogenesis of

Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Latz S, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Varma Pusapati G, Bullinger L, Franz WM, Koehntop R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, Boeckers TM, Liebau S. Circulation. 2010 Nov 2;122(18):1823-36.