| Name | eCF 309 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4011 |
| Prices | $165.00, $695.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 2001571-40-8 |
| Chemical Name | 3-(2-Amino-5-benzoxazolyl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Formula | C18H21N7O3 |
| Molecular Weight | 383.41 |
| Purity | >98 % |
| Description | Potent mTOR inhibitor (IC 50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC 50 = 8.5 nM). Cell permeable. |
| Supplier Page | Shop |
Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G. Cancer Res. 2005 Oct 1;65(19):9047-55.
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