Edelfosine

• Supplier: Tocris Bioscience
• Catalog: 0786
• Prices: $115.00
• Sizes: 10 mg
• Cas Number: 77286-66-9
• Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
• Formula: C27H58NO6P
• Molecular Weight: 523.73
• Description: Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC 50 = 9.6 μ M in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Product References

Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether - Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether

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A radioreceptor binding assay for platelet-activating factor (PAF) using - A radioreceptor binding assay for platelet-activating factor (PAF) using

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Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol - Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol

Shimizu T, Yamaguchi N, Okada S, Lu L, Sasaki T, Yokotani K. Eur J Pharmacol. 2007 Oct 1;571(2-3):138-44. Epub 2007 Jun 13.

Phospholipase C and myosin light chain kinase inhibition define a common step in - Phospholipase C and myosin light chain kinase inhibition define a common step in

Wong R, Fabian L, Forer A, Brill JA. BMC Cell Biol. 2007 May 17;8:15.