Eeyarestatin I

Name Eeyarestatin I
Supplier Tocris Bioscience
Catalog 2811
Prices $205.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 412960-54-4
Chemical Name 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Formula C27H25Cl2N7O7
Molecular Weight 630.44
Purity >98 %
Description Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.
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Product References

Inhibition of p97-dependent protein degradation by Eeyarestatin I. - Inhibition of p97-dependent protein degradation by Eeyarestatin I.

Wang Q, Li L, Ye Y. J Biol Chem. 2008 Mar 21;283(12):7445-54.

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular - Eeyarestatin 1 interferes with both retrograde and anterograde intracellular

Aletrari MO, McKibbin C, Williams H, Pawar V, Pietroni P, Lord JM, Flitsch SL, Whitehead R, Swanton E, High S, Spooner RA. PLoS One. 2011;6(7):e22713.