Efaroxan hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3922
• Prices: $135.00, $569.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 89197-00-2
• Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazolehydrochloride
• Formula: C13H16N2O.HCl
• Molecular Weight: 252.74
• Purity: >99 %
• Description: Potent, highly selective α 2 adrenoceptor antagonist and imidazoline I 1 receptor ligand (pK i values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A , α 2B , α 2C , I 1 , and I 2 receptors respectively). Promotes insulin secretion, at a site distinct from I 1 or I 2 (the putative I 3 receptor) in vitro and in vivo .

Product References

Alpha-adrenoreceptor reagents. 2. Effects of modification of the 1,4-benzodioxan - Alpha-adrenoreceptor reagents. 2. Effects of modification of the 1,4-benzodioxan

Chapleo CB, Myers PL, Butler RC, Davis JA, Doxey JC, Higgins SD, Myers M, Roach AG, Smith CF, Stillings MR, et al.. J Med Chem. 1984 May;27(5):570-6.

Imidazolines stimulate release of insulin from RIN-5AH cells independently from - Imidazolines stimulate release of insulin from RIN-5AH cells independently from

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'Seeing through a glass darkly': casting light on imidazoline 'I' sites. - 'Seeing through a glass darkly': casting light on imidazoline 'I' sites.

Eglen RM, Hudson AL, Kendall DA, Nutt DJ, Morgan NG, Wilson VG, Dillon MP. Trends Pharmacol Sci. 1998 Sep;19(9):381-90.

Effects of the imidazoline ligands efaroxan and KU14R on blood glucose - Effects of the imidazoline ligands efaroxan and KU14R on blood glucose

Mayer G, Taberner PV. Eur J Pharmacol. 2002 Nov 1;454(1):95-102.