| Name | EG 00229 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3733 |
| Prices | $245.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Cas Number | 1018927-63-3 |
| Chemical Name | N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine |
| Formula | C17H19N7O5S3 |
| Molecular Weight | 497.57 |
| Purity | >98 % |
| Description | Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro . Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). |
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