| Name | Eggmanone |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4524 |
| Prices | $155.00, $655.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 505068-32-6 |
| Chemical Name | 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one |
| Formula | C20H20N2O2S3 |
| Molecular Weight | 416.58 |
| Purity | >98 % |
| Description | Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC 50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1 . |
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