EHNA hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2807
• Prices: $89.00, $345.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 58337-38-5
• Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adeninehydrochloride
• Formula: C14H23N5O.HCl
• Molecular Weight: 313.83
• Purity: >98 %
• Description: Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC 50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

Product References

Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine - Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine

Bessodes M, Bastian G, Abushanab E, Panzica RP, Berman SF, Marcaccio EJ Jr, Chen SF, Stoeckler JD, Parks RE Jr. Biochem Pharmacol. 1982 Mar 1;31(5):879-82.

Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide - Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide

Podzuweit T, Nennstiel P, Muller A. Cell Signal. 1995 Sep;7(7):733-8.

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity - Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity

Michie AM, Lobban M, Muller T, Harnett MM, Houslay MD. Cell Signal. 1996 Feb;8(2):97-110.