Name | EHT 1864 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 1261 |
Prices | $209.00, $879.00 |
Sizes | 10 mg, 50 mg |
Function Type | Inhibitor |
Cas Number | 754240-09-0 |
Chemical Name | 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-onedihydrochloride |
Formula | C25H27F3N2O4S.2HCl |
Molecular Weight | 581.47 |
Purity | >98 % |
Description | Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo . |
Supplier Page | Shop |
Desire L, Bourdin J, Loiseau N, Peillon H, Picard V, De Oliveira C, Bachelot F, Leblond B, Taverne T, Beausoleil E, Lacombe S, Drouin D, Schweighoffer F. J Biol Chem. 2005 Nov 11;280(45):37516-25. Epub 2005 Sep 8.
Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ. J Biol Chem. 2007 Dec 7;282(49):35666-78. Epub 2007 Oct 11.
Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ. Methods Enzymol. 2008;439:111-29.