Eliprodil

• Supplier: Tocris Bioscience
• Catalog: 5316
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 119431-25-3
• Chemical Name: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
• Formula: C20H23ClFNO
• Molecular Weight: 347.86
• Purity: >98 %
• Description: Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

Product References

The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in - The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in

Bath CP, Farrell LN, Gilmore J, Ward MA, Hicks CA, O'Neill MJ, Bleakman D. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.

Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, - Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency,

Whittemore ER, Ilyin VI, Woodward RM. J Pharmacol Exp Ther. 1997 Jul;282(1):326-38.

Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance - Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance

Lengyel C, Dezsi L, Biliczki P, Horvath C, Virag L, Iost N, Nemeth M, Talosi L, Papp JG, Varro A. Br J Pharmacol. 2004 Sep;143(1):152-8. Epub 2004 Aug 9.