Embelin

• Supplier: Tocris Bioscience
• Catalog: 1860
• Prices: $119.00, $505.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 550-24-3
• Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
• Formula: C17H26O4
• Molecular Weight: 294.39
• Purity: >98 %
• Description: Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC 50 = 4.1 μ M in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC 50 4 - 6 μ M), but has a weaker effect on normal prostate cells (IC 50 = 19 - 20 μ M). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo .

Product References

Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. - Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.

Chitra M, Sukumar E, Suja V, Devi CS. Chemotherapy. 1994 Mar-Apr;40(2):109-13.

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of - Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of

Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S. J Med Chem. 2004 May 6;47(10):2430-40.

Probing p300/CBP associated factor (PCAF)-dependent pathways with a small - Probing p300/CBP associated factor (PCAF)-dependent pathways with a small

Modak R, Basha J, Bharathy N, Maity K, Mizar P, Bhat AV, Vasudevan M, Rao VK, Kok WK, Natesh N, Taneja R, Kundu TK. ACS Chem Biol. 2013;8(6):1311-23.