| Name | EMD 281014 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2156 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 443144-27-2 |
| Chemical Name | 7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrilehydrochloride |
| Formula | C22H21FN4O.HCl |
| Molecular Weight | 412.89 |
| Purity | >98 % |
| Description | Selective 5-HT 2A antagonist; displays high affinity for human 5-HT 2A over 5-HT 2C receptors (K i values are 0.87 and 557 nM respectively). Exhibits low off-target activity (K i values are >1000 and 1268 nM for human D 2 receptors and IKr channels, respectively). |
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Patel JG, Bartoszyk GD, Edwards E, Ashby CR Jr. Synapse. 2004 Apr;52(1):73-5.
Ladduwahetty T, Boase AL, Mitchinson A, Quin C, Patel S, Chapman K, MacLeod AM. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4. Epub 2006 May 2.