EML 425

• Supplier: Tocris Bioscience
• Catalog: 4209
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1675821-32-5
• Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
• Formula: C27H24N2O4
• Molecular Weight: 440.49
• Purity: >98 %
• Description: Reversible and non-competitive CBP/p300 inhibitor (IC 50 values are 1.1 and 2.9 μ M, respectively). Cell permeable.

Product References

Emodin-mediated protection from acute myocardial infarction via inhibition of - Emodin-mediated protection from acute myocardial infarction via inhibition of

Wu Y, Tu X, Lin G, Xia H, Huang H, Wan J, Cheng Z, Liu M, Chen G, Zhang H, Fu J, Liu Q, Liu DX. Life Sci. 2007 Oct 13;81(17-18):1332-8. Epub 2007 Sep 19.

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell - Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell

Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, Dan Z, Yan W. Eur J Pharmacol. 2010 Feb 10;627(1-3):33-41.

Neuroprotective effects of emodin in rat cortical neurons against - Neuroprotective effects of emodin in rat cortical neurons against

Liu T, Jin H, Sun QR, Xu JH, Hu HT. Brain Res. 2010 Aug 6;1347:149-60.