Endoxifen

• Supplier: Tocris Bioscience
• Catalog: 1197
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Cas Number: 112093-28-4
• Chemical Name: (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
• Formula: C25H27NO2
• Molecular Weight: 373.49
• Purity: >98 %
• Description: Estrogen receptor α (ER α ) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

Product References

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar - Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar

Lim YC, Li L, Desta Z, Zhao Q, Rae JM, Flockhart DA, Skaar TC. J Pharmacol Exp Ther. 2006 Aug;318(2):503-12. Epub 2006 May 11.

The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets - The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets

Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC. Cancer Res. 2009 Mar 1;69(5):1722-7.

Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic - Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic

Wu X, Subramaniam M, Grygo SB, Sun Z, Negron V, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Breast Cancer Res. 2011 Mar 10;13(2):R27.