Entacapone

Name Entacapone
Supplier Tocris Bioscience
Catalog 1693
Prices $59.00, $225.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 130929-57-6
Chemical Name (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Formula C14H15N3O5
Molecular Weight 305.29
Purity >99 %
Description Potent catechol O -methyltransferase (COMT) inhibitor (IC 50 values are 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively). Increases bioavailability of levodopa when given as an adjunct therapy for Parkinson's disease. Inhibits α -synuclein aggregation in an in vitro assay; blocks α -synuclein-induced cell death in PC-12 cells.
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Product References

Effect of entacapone, a peripherally acting catechol-O-methyltransferase - Effect of entacapone, a peripherally acting catechol-O-methyltransferase

Merello M, Lees AJ, Webster R, Bovingdon M, Gordin A. J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):186-9.

Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and - Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and

Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Jarvinen T, Mannisto PT. J Pharmacol Exp Ther. 2003 Feb;304(2):498-506.

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block - Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block

Di Giovanni S, Eleuteri S, Paleologou KE, Yin G, Zweckstetter M, Carrupt PA, Lashuel HA. J Biol Chem. 2010 May 14;285(20):14941-54.