Epirubicin hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0684
• Prices: $189.00
• Sizes: 10 mg
• Cas Number: 56390-09-1
• Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedionehydrochloride
• Formula: C27H29NO11.HCl
• Molecular Weight: 579.98
• Purity: >97 %
• Description: Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Product References

Epirubicin: a review of the pharmacology, clinical activity, and adverse effects - Epirubicin: a review of the pharmacology, clinical activity, and adverse effects

Cersosimo RJ, Hong WK. J Clin Oncol. 1986 Mar;4(3):425-39.

DNA polymerases and DNA topoisomerases as targets for the development of - DNA polymerases and DNA topoisomerases as targets for the development of

Spadari S, Pedrali-Noy G, Focher F, Montecucco A, Bordoni T, Geroni C, Giuliani FC, Ventrella G, Arcamone F, Ciarrocchi G. Anticancer Res. 1986 Sep-Oct;6(5):935-40.

Comparative activity of anthracycline 13-dihydrometabolites against rat - Comparative activity of anthracycline 13-dihydrometabolites against rat

Schott B, Robert J. Biochem Pharmacol. 1989 Nov 15;38(22):4069-74.