Eplerenone

• Supplier: Tocris Bioscience
• Catalog: 3260
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 107724-20-9
• Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylicacidγ-lactonemethylester
• Formula: C24H30O6
• Molecular Weight: 414.5
• Purity: >99 %
• Description: Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .

Product References

Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. - Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.

de Gasparo M, Joss U, Ramjoue HP, Whitebread SE, Haenni H, Schenkel L, Kraehenbuehl C, Biollaz M, Grob J, Schmidlin J, et al.. J Pharmacol Exp Ther. 1987 Feb;240(2):650-6.

Recent studies with eplerenone, a novel selective aldosterone receptor - Recent studies with eplerenone, a novel selective aldosterone receptor

McMahon EG. Curr Opin Pharmacol. 2001 Apr;1(2):190-6.