Eplivanserin hemifumarate

• Supplier: Tocris Bioscience
• Catalog: 2397
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 130580-02-8
• Chemical Name: (1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-oneO-[2-(dimethylamino)ethyl]oximehemifumarate
• Formula: C19H21FN2O2.0.5C4H4O4
• Molecular Weight: 386.42
• Purity: >98 %
• Description: Potent and selective 5-HT 2A antagonist (IC 50 values are 5.8 and 120 and >100 nM for 5-HT 2A , 5-HT 2B and 5-HT 2C , respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.

Product References

SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced - SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced

Bonaccorso S, Meltzer HY, Li Z, Dai J, Alboszta AR, Ichikawa J. Neuropsychopharmacology. 2002 Sep;27(3):430-41.

Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to - Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to

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Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists - Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists

Yadav PN, Kroeze WK, Farrell MS, Roth BL. J Pharmacol Exp Ther. 2011 Oct;339(1):99-105.