Epothilone B

Name Epothilone B
Supplier Tocris Bioscience
Catalog 2989
Prices $309.00
Sizes 100 µg
Cas Number 152044-54-7
Chemical Name (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Formula C27H41NO6S
Molecular Weight 507.68
Purity >98 %
Description Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro , including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC 50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo .
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Product References

Epothilones and related structures--a new class of microtubule inhibitors with - Epothilones and related structures--a new class of microtubule inhibitors with

Altmann KH, Wartmann M, O'Reilly T. Biochim Biophys Acta. 2000 May 17;1470(3):M79-91.

Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing - Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing

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Altered TUBB3 expression contributes to the epothilone response of mitotic cells. - Altered TUBB3 expression contributes to the epothilone response of mitotic cells.

Narvi E, Jaakkola K, Winsel S, Oetken-Lindholm C, Halonen P, Kallio L, Kallio MJ. Br J Cancer. 2013 Jan 15;108(1):82-90.